(R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone

Base Information

• Chemical Name: (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone
• CAS No.: 1198769-18-4
• Molecular Formula: C₃₂H₃₂N₂O₅
• Molecular Weight: 524.616
• Mol file: 1198769-18-4.mol

Synonyms:(R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone

Chemical Property of (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone

There total 5 articles about (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-3-nitrophenacyl bromide (43229-01-2) + (R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane (67346-60-5) → (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone (1198769-18-4)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 25 - 30 ℃; for 3h;

Reference yield:

benzylamine (100-46-9) → (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone (1198769-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / nickel / methanol / 65 - 70 °C / 7355.72 Torr

2.1: sodium hydroxide / water

2.2: 25 - 30 °C / Resolution of racemate; Reflux

3.1: sodium hydroxide / water / pH 9 - 10

4.1: potassium carbonate; potassium iodide / acetone / 3 h / 25 - 30 °C

With hydrogen; potassium carbonate; potassium iodide; sodium hydroxide; nickel; In methanol; water; acetone;

Reference yield:

4-methoxybenzyl methyl ketone (122-84-9) → (R)-4-benzyloxy-3-nitro-α-(N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amino)acetophenone (1198769-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / nickel / methanol / 65 - 70 °C / 7355.72 Torr

2.1: sodium hydroxide / water

2.2: 25 - 30 °C / Resolution of racemate; Reflux

3.1: sodium hydroxide / water / pH 9 - 10

4.1: potassium carbonate; potassium iodide / acetone / 3 h / 25 - 30 °C

With hydrogen; potassium carbonate; potassium iodide; sodium hydroxide; nickel; In methanol; water; acetone;

upstream raw materials:

4-benzyloxy-3-nitrophenacyl bromide

(R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane

(R)-N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amine L-mandelate

4-methoxybenzyl methyl ketone

Downstream raw materials:

(R,R)-3-nitro-α-[[[2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-4-(phenylmethoxy)-benzenemethanol

(R,R)-formoterol

(R,R)-3-amino-α-[[[2-(4-methoxyphenyl)-1-methylethyl](phenyl methyl)amino]methyl]-4-(phenylmethoxy)-benzenemethanol

N-[5-[(1R)-Hydroxy-2-[[(1R)-methyl-2-(4-methoxyphenyl)ethyl](phenylmethyl)amino]ethyl]-2-(phenylmethoxy)phenyl]-formamide