2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

Base Information

Chemical Name:2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride
CAS No.:117077-30-2
Molecular Formula:C₂₀H₂₆ClFN₂*ClH
Molecular Weight:385.352
Hs Code.:

Synonyms:2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

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Chemical Property of 2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

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Technology Process of 2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

There total 10 articles about 2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 41264-52-2
2-chloroethanimidic acid methyl ester

: 117077-24-4
2-[1-(4-Fluoro-phenyl)-adamantan-2-yl]-ethylamine; hydrochloride

: 117077-30-2
2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 12h;
DOI:10.1016/S0040-4020(01)90332-1

Reference yield:

: 27567-85-7
4-protoadamantanone

: 117077-30-2
2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 4 h / Heating

2: 0.5 h / Heating; reflux with 98percent HCOOH

3: 67 percent / 1 N HCl / acetone / 2 h / Heating

4: 94 percent / Jones reagent (CrO₃) / acetone; H₂O / 3.5 h / 15 °C

5: 97 percent / 50 percent NaH in paraffin / tetrahydrofuran / 0.17 h / 25 °C

6: 98 percent / H₂ / 10 percent Pd/C / ethanol / 30 h / 25 °C / 2068.6 Torr

7: 83 percent / 30 percent H₂O₂, 0.2 M aq. NaOH / methanol; dimethylsulfoxide / 12 h / 50 - 55 °C

8: 79 percent / 1.) H₄ 2.) HCl gas / tetrahydrofuran / 24 h / Heating

9: 73 percent / HCl / methanol / 12 h

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; 2,4,6,8-tetramethylcyclotetrasiloxane; hydrogen; dihydrogen peroxide; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4020(01)90332-1

Reference yield:

: 117077-02-8
1-(4-Fluoro-phenyl)-adamantan-2-ol

: 117077-30-2
2-Chloro-N-{2-[1-(4-fluoro-phenyl)-adamantan-2-yl]-ethyl}-acetamidine; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Jones reagent (CrO₃) / acetone; H₂O / 3.5 h / 15 °C

2: 97 percent / 50 percent NaH in paraffin / tetrahydrofuran / 0.17 h / 25 °C

3: 98 percent / H₂ / 10 percent Pd/C / ethanol / 30 h / 25 °C / 2068.6 Torr

4: 83 percent / 30 percent H₂O₂, 0.2 M aq. NaOH / methanol; dimethylsulfoxide / 12 h / 50 - 55 °C

5: 79 percent / 1.) H₄ 2.) HCl gas / tetrahydrofuran / 24 h / Heating

6: 73 percent / HCl / methanol / 12 h

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; 2,4,6,8-tetramethylcyclotetrasiloxane; hydrogen; dihydrogen peroxide; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4020(01)90332-1