N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

Base Information

Chemical Name:N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester
CAS No.:870822-45-0
Molecular Formula:C₄₀H₄₆NO₆P
Molecular Weight:667.782
Hs Code.:

Synonyms:N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

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Chemical Property of N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

Chemical Property:

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Technology Process of N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

There total 4 articles about N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₆ClO₂P

: 2768-50-5
dibenzyl L-glutamate

: 870822-45-0
N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

Guidance literature:: With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 15h;
DOI:10.1016/j.bmc.2005.07.056

Reference yield:

: 870822-42-7
[2-(4-cyclohexylphenyl)ethyl]phosphonic acid monobenzyl ester

: 870822-45-0
N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / cooling

2: 1H-tetrazole; ethyldiisopropylamine / tetrahydrofuran / 15 h / 0 - 20 °C

With 1H-tetrazole; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2005.07.056

Reference yield:

: 870822-39-2
dibenzyl [2-(4-cyclohexylphenyl)ethyl]phosphonate

: 870822-45-0
N-{benzyloxy[2-(4-cyclohexylphenyl)ethyl]phosphinyl}-L-glutamic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / cooling

2: 1H-tetrazole; ethyldiisopropylamine / tetrahydrofuran / 15 h / 0 - 20 °C

With 1H-tetrazole; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2005.07.056