Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester

Base Information

• Chemical Name: Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester
• CAS No.: 129436-58-4
• Molecular Formula: C₁₈H₃₃NO₃
• Molecular Weight: 311.465
• Mol file: 129436-58-4.mol

Synonyms:Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester

Chemical Property of Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester

There total 1 articles about Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Diethyl-carbamic acid (1S,6R)-6-acetyl-3-methyl-cyclohex-2-enyl ester (129436-54-0) + butyl magnesium bromide (693-04-9) → Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester (129436-58-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(00)88818-8

Reference yield: 100.0%

Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester (129436-58-4) → (1R,6S)-6-((R)-1-Hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enol (129436-59-5)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0040-4039(00)88818-8

Reference yield:

Diethyl-carbamic acid (1S,6R)-6-((S)-1-hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enyl ester (129436-58-4) → (R)-6-((R)-1-Hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enone (129436-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄

2: 57 percent / pyridinium chlorochromate, alumina / CH₂Cl₂

With aluminum oxide; lithium aluminium tetrahydride; pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/S0040-4039(00)88818-8

upstream raw materials:

Diethyl-carbamic acid (1S,6R)-6-acetyl-3-methyl-cyclohex-2-enyl ester

butyl magnesium bromide

Downstream raw materials:

(1R,6S)-6-((R)-1-Hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enol

(R)-6-((R)-1-Hydroxy-1-methyl-pentyl)-3-methyl-cyclohex-2-enone