4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CAS No.:77278-77-4
Molecular Formula:C16H23 F N2 O2
Molecular Weight:294.369
Hs Code.:2933599090
Mol file:77278-77-4.mol

Synonyms:4-(4-Fluorobenzyl)piperazine-1-carboxylicacid tert-butyl ester

Suppliers and Price of 4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 497.57

Total 2 raw suppliers

Chemical Property of 4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Vapor Pressure:1.41E-05mmHg at 25°C
Refractive Index:1.528
Boiling Point:367°C at 760 mmHg
Flash Point:175.7°C
PSA：32.78000
Density:1.139g/cm³
LogP:2.75420

Purity/Quality:

99% ^*data from raw suppliers

4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

There total 3 articles about 4-[(4-FLUOROPHENYL)METHYL]-1,1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 459-46-1
4-Fluorobenzyl bromide

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 77278-77-4
4-(4-fluorobenzyl)piperazine-1-tert-butoxycarbonyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 22h;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 77278-77-4
4-(4-fluorobenzyl)piperazine-1-tert-butoxycarbonyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bioorg.2019.103130

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 77278-77-4
4-(4-fluorobenzyl)piperazine-1-tert-butoxycarbonyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;