(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

Base Information

Chemical Name:(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane
CAS No.:191351-75-4
Molecular Formula:C₂₀H₁₉FN₄O
Molecular Weight:350.395
Hs Code.:

Synonyms:(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

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Technology Process of (S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

There total 5 articles about (S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 191351-78-7
(S)-2-fluoro-4-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propanol

: 191351-75-4
(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

Guidance literature:

Reference yield:

: methanesulfonic acid 1-benzyloxymethyl-2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl ester

: 191351-75-4
(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

Guidance literature:: With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; Yield given;
DOI:10.1021/jm981133m

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 191351-75-4
(S)-1-benzyloxy-2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propane

Guidance literature:: Multi-step reaction with 4 steps

2: 1.) LiCl, Na₂CO₃, Ph₃P, Pd(OAc)2, 2.) 5M HCl / 1.) DMF, 100 deg C, 20 h, 2.) EtOH, RT, 18 h

3: Et₃N / tetrahydrofuran / 1.5 h / Ambient temperature

4: TBAF / dimethylformamide

With hydrogenchloride; palladium diacetate; tetrabutyl ammonium fluoride; sodium carbonate; triethylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm981133m