(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

Base Information

Chemical Name:(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole
CAS No.:191351-74-3
Molecular Formula:C₂₀H₂₀N₄O₂
Molecular Weight:348.404
Hs Code.:

Synonyms:(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

Chemical Property:

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Technology Process of (R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

There total 3 articles about (R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

Ph₃ P: Ph₃ P

: 7732-18-5
water

: 497-19-8
sodium carbonate

: 177947-69-2
2-iodo-4-(1,2,4-triazol-4-yl)aniline

: 74-86-2,25067-58-7
acetylene

: 191351-74-3
(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

Guidance literature:: With hydrogenchloride; N₂; lithium chloride; palladium diacetate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 191351-74-3
(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) LiCl, Na₂CO₃, Ph₃P, Pd(OAc)2, 2.) 5M HCl / 1.) DMF, 100 deg C, 20 h, 2.) EtOH, RT, 18 h

With hydrogenchloride; palladium diacetate; sodium carbonate; triphenylphosphine; lithium chloride;
DOI:10.1021/jm981133m

Reference yield:

: 177947-69-2
2-iodo-4-(1,2,4-triazol-4-yl)aniline

: 191351-72-1
(R)-5-benzyloxy-4-hydroxy-1-triethylsilyl-1-pentyne

: 191351-74-3
(R)-3-(3-benzyloxy-2-hydroxyprop-1-yl)-5-(1,2,4-triazol-4-yl)-1H-indole

Guidance literature:: With hydrogenchloride; palladium diacetate; sodium carbonate; triphenylphosphine; lithium chloride; Yield given; Multistep reaction; 1.) DMF, 100 deg C, 20 h, 2.) EtOH, RT, 18 h;
DOI:10.1021/jm981133m