4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one

Base Information

• Chemical Name: 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one
• CAS No.: 843624-33-9
• Molecular Formula: C₁₇H₁₃ClN₄OS₂
• Molecular Weight: 388.901
• Mol file: 843624-33-9.mol

Synonyms:4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one

Chemical Property of 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one

There total 4 articles about 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

carbon disulfide (75-15-0,12122-00-8) + 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one → 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one (843624-33-9)

Guidance literature:

With pyridine; at 40 ℃; for 0.166667h;

DOI:10.13005/ojc/300209

Reference yield:

3-(4-chlorophenyl)-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one (111423-08-6) → 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one (843624-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 0.08 h / 100 °C

2: pyridine / 0.17 h / 40 °C

With pyridine; hydrazine hydrate; In ethanol;

DOI:10.13005/ojc/300209

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) → 4-(chlorophenyl)-1-mercapto-6,7,8,9-tetrahydrobenzo[b]thieno[2,3-b][1,2,4]triazolo[3,4-b]pyrimidin-5(4H)-one (843624-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 0.33 h / 120 °C / Microwave irradiation

2: hydrazine hydrate / ethanol / 0.08 h / 100 °C

3: pyridine / 0.17 h / 40 °C

With pyridine; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.13005/ojc/300209

upstream raw materials:

3-(4-chlorophenyl)-2-thioxo-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]-pyrimidin-4-one

carbon disulfide

4-Chlorophenyl isothiocyanate

2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid

Downstream raw materials:

C₁₈H₁₅ClN₄OS₂