4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

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Chemical Name:4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide
CAS No.:1604811-60-0
Molecular Formula:C₃₂H₂₃N₇O₃S
Molecular Weight:585.646
Hs Code.:

Synonyms:4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

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Chemical Property of 4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

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Technology Process of 4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

There total 7 articles about 4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 557-21-1
zinc(II) cyanide

: 1604811-59-7
4-amino-N-(3-((5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

: 1604811-60-0
4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In N,N-dimethyl acetamide; at 95 ℃; for 2h;

Reference yield:

: 1604811-55-3
tert-butyl 4-(3-(2-oxo-2-phenylethylideneamino)phenylcarbamoyl)phenylcarbamate

: 1604811-60-0
4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 760.05 Torr

2: 1-methyl-pyrrolidin-2-one / 0.5 h / 175 °C

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 2 h / 95 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl acetamide;

Reference yield:

: 66493-39-8
4-(N-tert-butoxycarbonyl)aminobenzoic acid

: 1604811-60-0
4-amino-N-(3-(5-cyano-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 760.05 Torr

3.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 175 °C

4.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 2 h / 95 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;