(2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

Base Information

Chemical Name:(2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol
CAS No.:181960-77-0
Molecular Formula:C₁₆H₃₄O₂Si
Molecular Weight:286.53
Hs Code.:

Synonyms:(2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

Suppliers and Price of (2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

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Chemical Property of (2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

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Technology Process of (2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

There total 2 articles about (2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 13834-16-7
(1R,2S,5R)-2-[(S)-2-hydroxy-1-methylethyl]-5-methylcyclohexan-1-ol

: 181960-77-0
(2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1039/cc9960001743

Reference yield:

: 20549-46-6
(+)-neoisopulegol

: 181960-77-0
(2S,5R)-2-[(S)-2-(tert-butyldimethylsilyloxy)-1-methylethyl]-5-methylcyclohexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / t-BuOOH / VO(acac)2 / benzene / 20 °C

2: 79 percent / NaBH₃CN; BF₃*OEt₂; bromocresol green / tetrahydrofuran / 12 h / 20 °C

3: 84 percent / imidazole / dimethylformamide / 0.25 h / 20 °C

With 1H-imidazole; tert.-butylhydroperoxide; boron trifluoride diethyl etherate; bromocresol green; sodium cyanoborohydride; bis(acetylacetonate)oxovanadium; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1039/b102961b