5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid

Base Information

• Chemical Name: 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid
• CAS No.: 1350612-58-6
• Molecular Formula: C₂₀H₁₆Cl₂N₂O₅S
• Molecular Weight: 467.329

Synonyms:5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid

Chemical Property of 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid

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Technology Process of 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid

There total 6 articles about 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methyl 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoate (1350612-60-0) → 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid (1350612-58-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 15h;

DOI:10.1016/j.jsbmb.2011.01.019

Reference yield:

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) → 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid (1350612-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorine; acetic acid / 0.5 h / 25 °C

2: piperidine / ethanol / 15 h / Reflux

3: lithium hydroxide / tetrahydrofuran; methanol / 15 h / 25 °C

With piperidine; chlorine; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

DOI:10.1016/j.jsbmb.2011.01.019

Reference yield:

methyl 5-(3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoate (1350612-64-4) → 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoic acid (1350612-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol / 15 h / Reflux

2: lithium hydroxide / tetrahydrofuran; methanol / 15 h / 25 °C

With piperidine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

DOI:10.1016/j.jsbmb.2011.01.019

upstream raw materials:

4-hydroxy-3-ethoxybenzaldehyde

methyl 2-chloro-5-(3-methylthioureido)benzoate

methyl 5-(3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoate

methyl 5-((Z)-5-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)-2-chlorobenzoate

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