(-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate

Base Information

• Chemical Name: (-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate
• CAS No.: 899216-37-6
• Molecular Formula: C₂₀H₂₄ClNO₂
• Molecular Weight: 345.869
• Mol file: 899216-37-6.mol

Synonyms:(-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate

Chemical Property of (-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate

There total 1 articles about (-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl (3R)-3-(benzylamino)-3-phenylpropanoate (190003-03-3) → (-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate (899216-37-6)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at -20 ℃;

DOI:10.1016/j.tet.2006.06.040

Reference yield:

(-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate (899216-37-6) → tert-butyl (R)-3-amino-3-phenylpropionate (161671-34-7)

Guidance literature:

(-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate; With N-dibutylamino-DBU; In toluene; at 20 ℃; for 24h;

With hydroxylamine hydrochloride; In tetrahydrofuran; water; at 20 ℃; for 0.25h;

DOI:10.1021/jo060588d

Reference yield:

(-)-tert-butyl (R)-3-(N-benzyl-N-chloroamino)-3-phenylpropanoate (899216-37-6) → (R)-3-Phenyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid tert-butyl ester + (Z)-tert-butyl 3-(benzylamino)-3-phenylacrylate

Guidance literature:

With N-dibutylamino-DBU; In toluene; at 20 ℃; for 24h; Title compound not separated from byproducts;

DOI:10.1021/jo060588d

upstream raw materials:

tert-butyl (3R)-3-(benzylamino)-3-phenylpropanoate

Downstream raw materials:

tert-butyl (R)-3-amino-3-phenylpropionate