TERT-BUTYL (3R)-3-AMINO-3-PHENYLPROPANOATE

Base Information

• Chemical Name: TERT-BUTYL (3R)-3-AMINO-3-PHENYLPROPANOATE
• CAS No.: 161671-34-7
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Hs Code.: 29224985
• Mol file: 161671-34-7.mol

Synonyms:Benzenepropanoicacid, b-amino-, 1,1-dimethylethyl ester,(R)-;(R)-3-Amino-3-phenylpropionic acid tert-butyl ester;tert-Butyl(3R)-3-amino-3-phenylpropanoate;

Chemical Property of TERT-BUTYL (3R)-3-AMINO-3-PHENYLPROPANOATE

Chemical Property:

• Appearance/Colour: Clear colorless to yellow slightly viscous liquid
• Vapor Pressure: 0.000354mmHg at 25°C
• Refractive Index: 1.496-1.498
• Boiling Point: 318.7 °C at 760 mmHg
• PKA: 7?+-.0.10(Predicted)
• Flash Point: 170.6 °C
• PSA: 52.32000
• Density: 1.04 g/cm³
• LogP: 3.11850

Purity/Quality:

98%Min ^*data from raw suppliers

Benzenepropanoicacid,?-amino-,1,1-dimethylethylester,(?R)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL (3R)-3-AMINO-3-PHENYLPROPANOATE

There total 53 articles about TERT-BUTYL (3R)-3-AMINO-3-PHENYLPROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-Butyl 3-(N-benzylamino)-3-phenylpropanoate (167628-35-5) → tert-butyl (R)-3-amino-3-phenylpropionate (161671-34-7)

Guidance literature:

With hydrogen; palladium hydroxide on carbon; In methanol; water; at 20 ℃; under 5320.36 Torr;

Reference yield: 94.0%

tert-butyl (3R)-3-(benzylamino)-3-phenylpropanoate (190003-03-3) → tert-butyl (R)-3-amino-3-phenylpropionate (161671-34-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 24h; under 5320 Torr;

DOI:10.1016/j.tet.2006.06.040

Reference yield: 89.0%

tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate (265669-72-5) → tert-butyl (R)-3-amino-3-phenylpropionate (161671-34-7)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In methanol; water; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1016/j.tetasy.2007.06.008

upstream raw materials:

(R)-tert-butyl 3-(benzhydrylamino)-3-phenylpropionate

(3R,αS)-tert-Butyl 3-(N-α-methyl-4-methoxybenzylamino)-3-phenyl propanoate

tert-butyl (R)-3-[N-(tert-butoxycarbonyl)amino]-3-phenylpropanoate

(3R,αS)-tert-Butyl 3-(N-benzyl-N-α-methyl-4-methoxybenzylamino)-3-phenyl propanoate

Downstream raw materials:

tert-butyl (3R)-3-(2-nitroanilino)-3-phenylpropanoate

(3R)-(naphthalene-2-sulfonamido)-3-phenylpropionic acid tert-butyl ester

(R)-N-(3-oxo-1-phenyl-3-(2-(piperidin-1-ylmethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)propyl)naphthalene-2-sulfonamide

(R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid