trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

Base Information

Chemical Name:trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile
CAS No.:1418003-15-2
Molecular Formula:C₁₉H₁₉N₇
Molecular Weight:345.407
Hs Code.:

Synonyms:trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

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Chemical Property of trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

Chemical Property:

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Technology Process of trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

There total 6 articles about trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418003-14-1
trans-[4-(2-chloromethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

: 1418003-15-2
trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1418003-15-2
trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 5 h / 0 - 20 °C

2: dimethyl sulfoxide / 4 h / 90 °C

3: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

5: ammonium chloride; iron / ethanol; water / 8.75 h / 80 °C

6: acetic acid / 0.5 h / 125 °C

7: sodium azide / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; sodium azide; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 683269-95-6
N-[trans-4-[[(methylsulfonyl)oxy]methyl]cyclohexyl]carbamic acid tert-butyl ester

: 1418003-15-2
trans-[4-(2-azidomethyl-imidazo[4,5-c]quinolin-1-yl)-cyclohexyl]-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

4: ammonium chloride; iron / ethanol; water / 8.75 h / 80 °C

5: acetic acid / 0.5 h / 125 °C

6: sodium azide / N,N-dimethyl-formamide / 4 h / 20 °C

With sodium azide; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;