1-(3-(Benzyloxy)phenyl)piperazine

Base Information

Chemical Name:1-(3-(Benzyloxy)phenyl)piperazine
CAS No.:756751-75-4
Molecular Formula:C₁₇H₂₀N₂O
Molecular Weight:268.359
Hs Code.:2933599090
DSSTox Substance ID:DTXSID30572245
Wikidata:Q82460534
Mol file:756751-75-4.mol

Synonyms:756751-75-4;1-(3-(Benzyloxy)phenyl)piperazine;1-(3-Benzyloxy-phenyl)-piperazine;1-(3-phenylmethoxyphenyl)piperazine;1-[3-(BENZYLOXY)PHENYL]PIPERAZINE;1-(3-benzyloxyphenyl)piperazine;MFCD04115063;SCHEMBL4671546;DTXSID30572245;PRIXVHNMFIDGKJ-UHFFFAOYSA-N;AKOS010941489;AB19549;CS-0340138;EN300-333337

Suppliers and Price of 1-(3-(Benzyloxy)phenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
500mg
$ 249.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
250mg
$ 175.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
100mg
$ 137.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
50mg
$ 117.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
25g
$ 1992.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
5g
$ 1590.00

J&W Pharmlab
1-(3-Benzyloxy-phenyl)-piperazine 95%
1g
$ 398.00

Crysdot
1-(3-(Benzyloxy)phenyl)piperazine 95+%
1g
$ 354.00

Chemenu
1-(3-(benzyloxy)phenyl)piperazine 95%
1g
$ 334.00

American Custom Chemicals Corporation
1-(3-BENZYLOXY-PHENYL)-PIPERAZINE 95.00%
5MG
$ 504.24

Total 10 raw suppliers

Chemical Property of 1-(3-(Benzyloxy)phenyl)piperazine

Chemical Property:

Vapor Pressure:2.69E-08mmHg at 25°C
Refractive Index:1.582
Boiling Point:450.2°C at 760 mmHg
PKA:8.93±0.10(Predicted)
Flash Point:226.1°C
PSA：24.50000
Density:1.106g/cm³
LogP:3.06900
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:268.157563266
Heavy Atom Count:20
Complexity:272

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Benzyloxy-phenyl)-piperazine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC(=CC=C2)OCC3=CC=CC=C3

Technology Process of 1-(3-(Benzyloxy)phenyl)piperazine

There total 2 articles about 1-(3-(Benzyloxy)phenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,1-dimethylethyl 4-[3-(phenylmethoxy)phenyl]-1-piperazinecarboxylate

: 756751-75-4
1-[3-(benzyloxy)phenyl]piperazine

Guidance literature:: 1,1-dimethylethyl 4-[3-(phenylmethoxy)phenyl]-1-piperazinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

With ammonium hydroxide; In water;
DOI:10.1021/acschemneuro.0c00257

Reference yield:

: 53087-13-1
3-(benzyloxy)phenyl bromide

: 756751-75-4
1-[3-(benzyloxy)phenyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/acschemneuro.0c00257