2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Base Information

Chemical Name:2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester
CAS No.:910456-78-9
Molecular Formula:C₁₇H₁₈ClNO₇
Molecular Weight:383.785
Hs Code.:

Synonyms:2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Suppliers and Price of 2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

There total 3 articles about 2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 141-97-9
ethyl acetoacetate

: 591250-18-9
methyl 2-[acetyloxymethyl(5-chloro-2-nitrophenyl)]acrylate

: 910456-78-9
2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: methyl 2-[acetyloxymethyl(5-chloro-2-nitrophenyl)]acrylate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

ethyl acetoacetate; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2006.06.098

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 910456-78-9
2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: DABCO / 20 °C

2.1: pyridine / CH₂Cl₂ / 20 °C

3.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

3.2: 75 percent / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water; 1.1: Baylis-Hillman reaction;
DOI:10.1016/j.tet.2006.06.098

Reference yield:

: 528861-97-4
methyl 3-(5-chloro-2-nitrophenyl)-3-hydroxy-2-methylenepropanoate

: 910456-78-9
2-acetyl-3-(5-chloro-2-nitro-phenyl)-4-methylene-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 20 °C

2.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

2.2: 75 percent / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2006.06.098