(1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid

Base Information

• Chemical Name: (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid
• CAS No.: 109977-08-4
• Molecular Formula: C₂₂H₁₈N₂O₆
• Molecular Weight: 406.395

Synonyms:(1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid

Chemical Property of (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid

Chemical Property:

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Technology Process of (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid

There total 2 articles about (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl (1α,2α,3β,4β)-1,3-dicyano-2,4-bis-o-methoxyphenylcyclobutane-1,3-dicarboxylate (109977-07-3) → (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid (109977-08-4)

Guidance literature:

With potassium hydroxide; In ethanol; acetone; at 40 - 45 ℃; for 0.75h;

DOI:10.1021/jo00232a013

Reference yield:

(E)-2-cyano-3-(2-methoxyphenyl)-2-propenoic acid ethyl ester (14533-89-2) → (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid (109977-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 4 h / Irradiation

2: 90 percent / KOH in ethanol / acetone; ethanol / 0.75 h / 40 - 45 °C

With potassium hydroxide; In ethanol; acetone;

DOI:10.1021/jo00232a013

Reference yield:

(1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid (109977-08-4) → 2,4-Bis-(2-methoxy-phenyl)-cyclobutane-1,3-dicarbonitrile (110043-35-1) + (1α,2α,3α,4β)-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dinitryle (109977-09-5)

Guidance literature:

at 195 - 210 ℃; for 0.05h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00232a013

upstream raw materials:

diethyl (1α,2α,3β,4β)-1,3-dicyano-2,4-bis-o-methoxyphenylcyclobutane-1,3-dicarboxylate

(E)-2-cyano-3-(2-methoxyphenyl)-2-propenoic acid ethyl ester

Downstream raw materials:

2,4-Bis-(2-methoxy-phenyl)-cyclobutane-1,3-dicarbonitrile

(1α,2α,3α,4β)-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dinitryle

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