14533-89-2

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 135-02-4 ortho-anisaldehyde 
• 122604-91-5 C₁₇H₂₁N₅O₃ 
• 64-19-7 acetic acid 
• 22621-54-1 2-Methoxy phenyl methylene-propanedioic acid dimethyl ester 
• 64-17-5 ethanol 
• 882653-23-8 2-cyano-3c-(2-methoxy-phenyl)-acrylic acid 
• 90-02-8 salicylaldehyde 
• 612-16-8 (2-methoxyphenyl)methanol 
• 7677-24-9 trimethylsilyl cyanide 
• 80220-94-6 ethyl 3-(2-methoxyphenyl)prop-2-ynoate 
• 6850-57-3 2-methoxybenzylamine 
• 105-34-0 methyl 2-cyanoacetate 
• 103964-31-4 C₁₁H₁₆N₄O 

Downstream Products

• 133828-96-3 (2S,3S,8aR)-3-Carbamoyl-1,6-dicyano-2-(2-methoxy-phenyl)-1,2,3,8a-tetrahydro-indolizine-1-carboxylic acid ethyl ester 
• 591-31-1 3-methoxy-benzaldehyde 
• 333341-16-5 2-amino-4-(2-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylic acid ethyl ester 
• 333340-99-1 2-amino-4-(2-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylic acid ethyl ester 
• 1385784-09-7 ethyl-2-amino-5-cyano-1-[1-(2,5-dimethoxyphenyl)ethylideneamino]-6-oxo-4-(2-methoxyphenyl)-1,6-dihydropyridine-3-carboxylate 
• 100372-58-5 ethyl 2-cyano-3-(2-methoxyphenyl)propanoate 
• 773091-15-9 ethyl 2-cyano-5-(2-methoxyphenyl)penta-2,4-dienoate 
• 109977-07-3 diethyl (1α,2α,3β,4β)-1,3-dicyano-2,4-bis-o-methoxyphenylcyclobutane-1,3-dicarboxylate 
• 10493-37-5 3-(2-methoxyphenyl)propan-1-ol 
• 109977-08-4 (1α,2α,3β,4β)-1,3-dicyano-2,4-bis(2-methoxyphenyl)cyclobutane-1,3-dicarboxylic acid 
• 91144-07-9 3-(2-Methoxyphenyl)succinic acid 
• 479611-61-5 1,3-dicyano-2,4-bis-(2-methoxy-phenyl)-cyclobutane-1,3-dicarboxylic acid diethyl ester 
• 1011-54-7 2-methoxycinnamic acid 
• 6342-77-4 2-methoxy-benzenepropanoic acid 

Relevant academic research and scientific papers

Green condensation reaction of aromatic aldehydes with active methylene compounds catalyzed by anion-exchange resin under ultrasound irradiation

To realize a practical and green chemistry, two important challenges need to be addressed, namely the effective process for the activation of reaction and efficient, eco-friendly and robust chemical methods for the reaction conversion to target products v

Organophosphonate-Functionalized Telluromolybdate Containing a [TeMo10O37]10-Building Block and Its Catalytic Efficiency for Knoevenagel Condensation

A novel organodiphosphonate-based telluromolybdate cluster, (NH4)6Na3H13[TeMo10O37(CoMo2O6L)4]·11H2O [1; L = (O3P)2C(O)(CH2)3NH2], has been successfully synthesized by a simple one-pot aqueous reaction. Intriguingly, the [TeMo10O37]10- subunit with tetrah

trans-Selective hydrocyanation of ynoates, ynones and ynoic acids catalyzed by nucleophilic phosphines

trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alcohol additive are catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne are produced with high regio- and stereoselectivity. The alcohol additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids undergo the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacts with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gives the stereo-defined E-2-cyano-acrylic acids after work up.

Novel Application of Polymer Networks Carrying Tertiary Amines as a Catalyst Inside Microflow Reactors Used for Knoevenagel Reactions

A novel application is described for utilizing hydrogel dots as organocatalyst carriers inside microfluidic reactors. Tertiary amines were covalently immobilized in the hydrogel dots. Due to the diffusion of reactants within the swollen hydrogel dots, the

Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation

In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]

Synthesis and Characterization of a Crown-Shaped 36-Molybdate Cluster and Application in Catalyzing Knoevenagel Condensation

A novel crown-shaped 36-molybdate cluster with organophosphonate-functionalized polyoxomolybdates, (NH4)17Na7H12[Co(H2O)TeMo6O21{N(CH2PO3)3}]6·42H2O, has been successfully synthesized and well-characterized. It owns the highest nuclearity in the family of organophosphonate-based polyoxometalates reported so far. Furthermore, for the first time in the field, we illustrated that polyoxomolybdate could work as an effective heterogeneous catalyst for the Knoevenagel condensation reaction with high TOF (7714 h-1) and good recyclability. Impressively, the catalytic performance of 1 was also tested successfully in a large scale (～10 g) reaction, where 89percent of reaction yield and 3216 of TON were afforded.

Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].

Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Layered double hydroxide anchored ionic liquids as amphiphilic heterogeneous catalysts for the Knoevenagel condensation reaction

In recent years, great attention has been dedicated to the development of heterogeneous base catalysts providing a green and sustainable process in benign aqueous media. Herein, the ionic liquid modified layered double hydroxide (LDH) based catalysts of L

l-Lysine Functionalized Polyacrylonitrile Fiber: A Green and Efficient Catalyst for Knoevenagel Condensation in Water

Abstract: The l-lysine functionalized polyacrylonitrile fiber (PANLF) was prepared by grafting the l-lysine into a commercially available polyacrylonitrile fiber and showed highly catalytic activity for Knoevenagel condensation reaction. With low temperature (45?°C) and short reaction time (1?h), the fiber catalyst was well applicable to Knoevenagel condensation of a wide range of aldehydes and the yields could reach up to 99%. Interestingly, only in water could the reaction take place smoothly (with a yield of 88%) and a polar micro-environment promoted reaction process had been proposed to explain this phenomenon. Besides, the fiber catalyst has advantages of easy preparation, high functional degree, strong mechanical strength and thermal stability, etc. And it can be reused at least 5 times without further treatment and performed well in scaled-up experiment (amplified 50 times) and flow chemistry experiment (no loss of catalytic activity after 48?h), which indicates its potential application in industry application. Graphical Abstract: [Figure not available: see fulltext.].