4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

Base Information

Chemical Name:4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol
CAS No.:1260432-29-8
Molecular Formula:C₂₂H₂₁N₅O
Molecular Weight:371.442
Hs Code.:

Synonyms:4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

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Chemical Property of 4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

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Technology Process of 4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

There total 7 articles about 4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1260432-13-0
2-(4-methoxy-3,5-dimethylphenyl)-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-4-amine

: 1260432-29-8
4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1260432-29-8
4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

2.1: methanol / 40 - 60 °C

3.1: ammonia / methanol / 67 °C

4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4.5 h / 80 - 90 °C

5.1: boron tribromide / dichloromethane / 18 h / 0 - 20 °C

With n-butyllithium; ammonia; boron tribromide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 1260432-29-8
4-(4-amino-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-2-yl)-2,6-dimethylphenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 136 °C

2.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

3.1: methanol / 40 - 60 °C

4.1: ammonia / methanol / 67 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 4.5 h / 80 - 90 °C

6.1: boron tribromide / dichloromethane / 18 h / 0 - 20 °C

With n-butyllithium; ammonia; boron tribromide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;