benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

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Chemical Name:benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate
CAS No.:1374138-06-3
Molecular Formula:C₃₅H₄₉FN₂O₃Si
Molecular Weight:592.87
Hs Code.:

Synonyms:benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

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Chemical Property of benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

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Technology Process of benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

There total 11 articles about benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-05-2
benzyl [(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluoro-6-(tritylamino)hexan-2-yl](3-methylbutyl)carbamate

: 1374138-06-3
benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

Guidance literature:: benzyl [(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluoro-6-(tritylamino)hexan-2-yl](3-methylbutyl)carbamate; With trifluoroacetic acid; In 1,2-dichloro-ethane; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: C₂₂H₃₃NO₂Si*ClH

: 1374138-06-3
benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 20 °C

2.1: sodium hydrogencarbonate / chloroform; water / 1 h / 20 °C

3.1: 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve

3.2: 3 h / 20 °C

4.1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 4-methylmorpholine N-oxide; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 1374138-02-9
benzyl [(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}-6-hydroxyhexan-2-yl](3-methylbutyl)carbamate

: 1374138-06-3
benzyl [(2S)-6-amino-1-{[tert-butyl(diphenyl)silyl]oxy}-5-fluorohexan-2-yl](3-methylbutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 3 h / 20 °C

2.1: N-fluorobis(benzenesulfon)imide; 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt / isopropyl alcohol; tetrahydrofuran / 24 h / -20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 0 °C

With 5-benzyl-2,2,3-trimethylimidazolidin-4-one dichloroacetic acid salt; sodium tris(acetoxy)borohydride; 4-methylmorpholine N-oxide; N-fluorobis(benzenesulfon)imide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;