3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

Base Information

Chemical Name:3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid
CAS No.:1297309-28-4
Molecular Formula:C₁₃H₁₁ClN₂O₃S
Molecular Weight:310.761
Hs Code.:

Synonyms:3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

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Chemical Property of 3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

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Technology Process of 3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

There total 2 articles about 3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.5%

: 280108-15-8
(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

: 79-04-9
chloroacetyl chloride

: 1297309-28-4
3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

Guidance literature:: (2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid; chloroacetyl chloride; With sodium hydrogencarbonate; In water; at 20 ℃;

With citric acid; In water; pH=2 - 3;
DOI:10.1016/j.bmc.2011.02.019

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1297309-28-4
3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethanol; water / 6 h

2.1: sodium hydrogencarbonate / water / 20 °C

2.2: pH 2 - 3

With sodium hydrogencarbonate; In ethanol; water;
DOI:10.1016/j.bmc.2011.02.019

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1297309-28-4
3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid

: C₁₈H₂₁N₃O₅S

Guidance literature:: 3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid; With ammonium hydroxide; In water; for 72h;

di-tert-butyl dicarbonate; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 12h;

With citric acid; In water; pH=2 - 3;
DOI:10.1016/j.bmc.2011.02.019