β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

Base Information

Chemical Name:β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester
CAS No.:195301-88-3
Molecular Formula:C₂₂H₃₀N₂O₇
Molecular Weight:434.489
Hs Code.:

Synonyms:β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

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Chemical Property of β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

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Technology Process of β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

There total 3 articles about β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: α-methyl β-benzyl (2R)-aspartate diester hydrochloride

: 195301-88-3
β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 12h; upto r.t.;
DOI:10.1016/S0040-4039(97)01253-7

Reference yield:

: 84890-94-8
(S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: α-methyl β-benzyl (2R)-aspartate diester hydrochloride

: 195301-88-3
β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃; for 12h;
DOI:10.1039/b100401h

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 195301-88-3
β-benzyl [(2S)-N-(tert-butoxycarbonyl)prolyl][α-methyl (2R)-aspartate] diester

Guidance literature:: Multi-step reaction with 2 steps

1: NMM / tetrahydrofuran; dimethylformamide / 0.08 h / -15 °C

2: 343 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b100401h