(1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester
• CAS No.: 856448-69-6
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 856448-69-6.mol

Synonyms:(1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Chemical Property of (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

There total 1 articles about (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1S,2R,3R)-1-t-butoxycarbonylamino-2-methyl-3-phenyl-cyclopropanecarboxylic acid t-butyl ester (856432-51-4) → (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester (856448-69-6)

Guidance literature:

With toluene-4-sulfonic acid; In acetonitrile; at 0 - 20 ℃; for 16h;

Reference yield: 82.0%

5-(4-iodo-pyrazole-1-yl)-thiophene-2-sulfonyl chloride (856449-02-0) + (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester (856448-69-6) → (1S,2R,3R)-1-[5-(4-iodo-pyrazole-1-yl)-thiophene-2-sulfonylamino-2-methyl-3-phenyl]-cyclopropanecarboxylic acid t-butyl ester

Guidance literature:

With triethylamine; In chloroform; at 20 - 50 ℃; for 2h;

Reference yield: 69.0%

5-bromo-2-thiophenesulfonyl chloride (55854-46-1) + (1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester (856448-69-6) → (1S,2R,3R)-1-(5-bromothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:

With pyridine; at 0 - 20 ℃; for 12h;

DOI:10.1021/jm101609j

upstream raw materials:

(1S,2R,3R)-1-t-butoxycarbonylamino-2-methyl-3-phenyl-cyclopropanecarboxylic acid t-butyl ester

Downstream raw materials:

C₂₄H₂₄ClN₃O₄S₂

(1S,2R,3R)-1-[5-(5-chloropyridin-2-yl)-4-nitrothiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

(1S,2R,3R)-1-[5-(4-chloro-2-nitrophenyl)thiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

(1S,2R,3R)-1-[5-(4-fluoro-2-nitrophenyl)thiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester