Cyclohexanecarboxaldehyde, 1-acetyl- (9CI)

Base Information

• Chemical Name: Cyclohexanecarboxaldehyde, 1-acetyl- (9CI)
• CAS No.: 756491-88-0
• Molecular Formula: C9H14 O2
• Molecular Weight: 154.209
• Mol file: 756491-88-0.mol

Synonyms:Cyclohexanecarboxaldehyde, 1-acetyl- (9CI)

Chemical Property of Cyclohexanecarboxaldehyde, 1-acetyl- (9CI)

Chemical Property:

• PSA: 34.14000
• LogP: 1.72480

Purity/Quality:

SPIROCYCLOHEXYLBUTANE-1,3-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxaldehyde, 1-acetyl- (9CI)

There total 3 articles about Cyclohexanecarboxaldehyde, 1-acetyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

4-(cyclohexylidenemethyl)morpholine (16963-29-4) + acetyl chloride (75-36-5) → 1-acetyl-cyclohexanecarboxaldehyde (756491-88-0)

Guidance literature:

In dichloromethane; at 45 ℃; for 4h;

DOI:10.1021/jo062264v

Reference yield:

C13H22NO2(1+)*Cl(1-) → 1-acetyl-cyclohexanecarboxaldehyde (756491-88-0)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0033-1340857

Reference yield:

4-(cyclohexylidenemethyl)morpholine (16963-29-4) → 1-acetyl-cyclohexanecarboxaldehyde (756491-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 10 h / 0 °C / Reflux; Inert atmosphere

2: sodium hydrogencarbonate / water / 1 h / 0 °C / Inert atmosphere

With sodium hydrogencarbonate; In diethyl ether; water;

DOI:10.1055/s-0033-1340857

upstream raw materials:

4-(cyclohexylidenemethyl)morpholine

acetyl chloride

Downstream raw materials:

ethyl 3-[1-(1-trimethylsilanyloxyvinyl)cyclohexyl]acrylate

1-[1-(2,2-difluorovinyl)cyclohexyl]ethanone

N-{1-[1-(2,2-difluorovinyl)cyclohexyl]ethylidene}-4-methylbenzenesulfonamide

3-fluoro-1-methylene-2-[(4-tolyl)sulfonyl]-2-azaspiro[4.5]dec-3-ene