allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate

Base Information

• Chemical Name: allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate
• CAS No.: 914912-83-7
• Molecular Formula: C₂₈H₃₇BN₂O₆
• Molecular Weight: 508.423
• Mol file: 914912-83-7.mol

Synonyms:allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate

Chemical Property of allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate

There total 4 articles about allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

allyl 3-amino-5-(tert-butoxycarbonylamino)benzoate (914912-82-6) + 2,3-dimethyl-2,3-butane diol (76-09-5) + 2-formylbenzene boronic acid (40138-16-7) → allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate (914912-83-7)

Guidance literature:

allyl 3-amino-5-(tert-butoxycarbonylamino)benzoate; 2-formylbenzene boronic acid; With sodium cyanoborohydride; acetic acid; In ethanol; at 20 ℃; for 32h;

2,3-dimethyl-2,3-butane diol; In toluene; Heating;

DOI:10.1002/ejoc.200600245

Reference yield:

allyl 3,5-bis(tert-butoxycarbonylamino)benzoate (914912-81-5) → allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate (914912-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCl / dioxane / 2 h / 0 - 5 °C

2.1: 8.2 g / N-ethyldiisopropylamine / CH₂Cl₂ / 5 - 20 °C

3.1: sodium cyanoborohydride; acetic acid / ethanol / 32 h / 20 °C

3.2: 60 percent / toluene / Heating

With hydrogenchloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1002/ejoc.200600245

Reference yield:

3,5-diamino-benzoic acid allyl ester; compound with GENERIC INORGANIC NEUTRAL COMPONENT → allyl 3-(tert-butoxycarbonylamino)-5-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamino]benzoate (914912-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 8.2 g / N-ethyldiisopropylamine / CH₂Cl₂ / 5 - 20 °C

2.1: sodium cyanoborohydride; acetic acid / ethanol / 32 h / 20 °C

2.2: 60 percent / toluene / Heating

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1002/ejoc.200600245

upstream raw materials:

allyl 3-amino-5-(tert-butoxycarbonylamino)benzoate

2,3-dimethyl-2,3-butane diol

2-formylbenzene boronic acid

allyl 3,5-bis(tert-butoxycarbonylamino)benzoate

Downstream raw materials:

allyl 3-(tert-butoxycarbonylamino)-5-{methyl[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]amino}benzoate

2-(3-allyloxycarbonyl-5-{methyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-amino}-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

C₄₀H₄₄B₂N₆O₈

C₅₂H₆₄B₂N₆O₈