tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate
CAS No.:1288341-00-3
Molecular Formula:C₂₆H₃₅N₅O₃
Molecular Weight:465.596
Hs Code.:

Synonyms:tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

There total 7 articles about tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1288342-41-5
N-[4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenyl]-2-(piperazin-1-yl)acetamide

: 1288341-00-3
tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 1288341-00-3
tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / dimethyl sulfoxide / 60 °C

2.1: hydrazine hydrate / ethanol / Reflux

3.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 160 °C / Inert atmosphere

3.2: 4 h / 160 °C

4.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux

5.1: dichloromethane / 0.25 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0 - 28 °C

7.1: triethylamine / dichloromethane

With sodium ethanolate; iron; sodium hydride; ammonium chloride; caesium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 30923-64-9
1,3-dicyclopropylpropane-1,3-dione

: 1288341-00-3
tert-butyl 4-(2-(4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / ethanol / Reflux

2.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 160 °C / Inert atmosphere

2.2: 4 h / 160 °C

3.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux

4.1: dichloromethane / 0.25 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0 - 28 °C

6.1: triethylamine / dichloromethane

With iron; sodium hydride; ammonium chloride; caesium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;