8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

Base Information

Chemical Name:8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline
CAS No.:933796-09-9
Molecular Formula:C₂₂H₂₂F₂N₂O₂S
Molecular Weight:416.492
Hs Code.:

Synonyms:8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

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Chemical Property of 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

Chemical Property:

Purity/Quality:

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Technology Process of 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

There total 6 articles about 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 933796-28-2
8-[(3,3-difluoro-1-piperidinyl)methyl]-3-iodoquinoline

: 824-79-3
sodium 4-methylbenzenesulfinate

: 933796-09-9
8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine; In dimethyl sulfoxide; at 100 ℃; for 2h;

Reference yield:

: 7496-46-0
8-bromomethyl-quinoline

: 933796-09-9
8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / Heating / reflux

1.2: 0.5 h

2.1: potassium hydroxide; water / methanol / 2 h / Heating / reflux

3.1: manganese(IV) oxide / dichloromethane / 4.5 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

5.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 2 h / 100 °C

With manganese(IV) oxide; potassium hydroxide; N-iodo-succinimide; copper(l) iodide; water; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N,N-dimethylethylenediamine; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 611-32-5
8-methylquinoline

: 933796-09-9
8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-methylphenyl)sulfonyl]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Heating / reflux

2.1: N-iodo-succinimide / Heating / reflux

2.2: 0.5 h

3.1: potassium hydroxide; water / methanol / 2 h / Heating / reflux

4.1: manganese(IV) oxide / dichloromethane / 4.5 h / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

6.1: copper(l) iodide; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 2 h / 100 °C

With manganese(IV) oxide; potassium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; copper(l) iodide; water; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N,N-dimethylethylenediamine; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide;