Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 117824-84-7
• Molecular Formula: C₄₄H₅₀N₃O₁₀P
• Molecular Weight: 811.869

Synonyms:Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property of Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 4 articles about Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-1-hexanol (4048-33-3) → Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (117824-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1H-tetrazole, I₂

With 1H-tetrazole; iodine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1248/cpb.36.1386

Reference yield:

3'-O-benzoylthymidine (17331-53-2) → Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (117824-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂ / 1 h / 30 °C

2: 1H-tetrazole, I₂

With 1H-tetrazole; N,N-diisopropylamine tetrazolide; iodine; In dichloromethane;

DOI:10.1248/cpb.36.1386

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → Benzoic acid (2R,3S,5R)-2-[methoxy-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyloxy)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (117824-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1H-tetrazole, I₂

With 1H-tetrazole; iodine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1248/cpb.36.1386

upstream raw materials:

1-hydroxy-6-((4-methoxyphenyl)-diphenylmethylamino)-hexane

Benzoic acid (2R,3S,5R)-2-(diisopropylamino-methoxy-phosphanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

6-amino-1-hexanol

3'-O-benzoylthymidine

Downstream raw materials:

Phosphoric acid (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

Phosphoric acid (2R,3S,5R)-3-(diisopropylamino-methoxy-phosphanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexyl ester methyl ester

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