N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Base Information

Chemical Name:N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride
CAS No.:1256726-32-5
Molecular Formula:C₁₇H₁₆F₃NO₃S*ClH
Molecular Weight:407.841
Hs Code.:

Synonyms:N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Suppliers and Price of N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

There total 6 articles about N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₄F₃NO₄S

: 1256726-32-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: C₁₇H₁₄F₃NO₄S; With borane-THF; In tetrahydrofuran; at 0 ℃; for 2h; Heating;

With hydrogenchloride; In tetrahydrofuran; ethyl acetate; at 70 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.07.071

Reference yield:

: 1191908-73-2
6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

: 1256726-32-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-[2-(methylsulfanyl)phenyl]acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating

2.2: 2 h / 70 °C

With borane-THF; 2-[2-(methylsulfanyl)phenyl]acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2017.07.071

Reference yield:

: 21243-18-5
6-fluoro-3,4-dihydro-2H-1-benzothiopyran-4-one

: 1256726-32-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 16 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Heating

3.1: ethyl acetate / 2 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 0 - 20 °C

5.1: 2-[2-(methylsulfanyl)phenyl]acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C

6.1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating

6.2: 2 h / 70 °C

With pyridine; borane-THF; 2-[2-(methylsulfanyl)phenyl]acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2017.07.071