Technology Process of N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride
There total 6 articles about N-[2-(2,5-difluorophenoxy)ethyl]-6-fluoro-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C17H14F3NO4S;
With
borane-THF;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Heating;
With
hydrogenchloride;
In
tetrahydrofuran; ethyl acetate;
at 70 ℃;
for 2h;
DOI:10.1016/j.ejmech.2017.07.071
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2-[2-(methylsulfanyl)phenyl]acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C
2.1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating
2.2: 2 h / 70 °C
With
borane-THF; 2-[2-(methylsulfanyl)phenyl]acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2017.07.071
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / 16 h / 20 °C
2.1: borane-THF / tetrahydrofuran / 4 h / 0 °C / Heating
3.1: ethyl acetate / 2 h / 20 °C
4.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 0 - 20 °C
5.1: 2-[2-(methylsulfanyl)phenyl]acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 20 °C
6.1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating
6.2: 2 h / 70 °C
With
pyridine; borane-THF; 2-[2-(methylsulfanyl)phenyl]acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2017.07.071