21243-18-5

Basic information

• Product Name: 6-FLUOROTHIO-4-CHROMANONE
• Synonyms: BUTTPARK 29\07-31;6-FLUORO-2,3-DIHYDRO-4H-THIOCHROMEN-4-ONE;6-FLUORO-3,4-DIHYDRO-2H-1-BENZOTHIIN-4-ONE;6-FLUOROTHIO-4-CHROMANONE;6-Fluorothiochroman-4-one;6-Fluoro-2,3-dihydro-4h-thiochromen-4-one, 95+%;6-Fluorothiochroman-4-one 97%;6-Fluorothiochroman-4-one97%
• CAS NO: 21243-18-5
• Molecular Formula: C₉H₇FOS
• Molecular Weight: 182.21
• Mol File: 21243-18-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 89-92
• Boiling Point: 304.271 °C at 760 mmHg
• Flash Point: 137.819 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 0.000883mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 6-FLUOROTHIO-4-CHROMANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROTHIO-4-CHROMANONE(21243-18-5)
• EPA Substance Registry System: 6-FLUOROTHIO-4-CHROMANONE(21243-18-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 21243-18-5(Hazardous Substances Data)

Usage

General Description

6-Fluorothio-4-chromanone is a chemical compound with the molecular formula C9H7FO2S. It is a heterocyclic organic compound that contains a fluorine atom and a sulfur atom, as well as a chromanone ring. 6-FLUOROTHIO-4-CHROMANONE has potential applications in pharmaceutical research and drug development due to its unique structure and properties. It may have uses in the field of medicinal chemistry as a potential drug candidate or as a building block for synthesizing other bioactive molecules. Further research into the properties and potential applications of 6-fluorothio-4-chromanone is warranted to fully understand its capabilities and limitations.

InChI:InChI=1/C9H7FOS/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-2,5H,3-4H2

Upstream product

• 19543-85-2 3-(4-fluorophenylthio)propanoic acid 
• 107-94-8 chloropropionic acid 
• 371-42-6 4-Fluorothiophenol 
• 3887-61-4 sodium 4-fluorophenylthiolate 
• 79-37-8 oxalyl dichloride 
• 682760-24-3 3-p-fluorobenzenesulfonyl propionic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1178529-19-5 C₂₄H₁₈FNO₂S 
• 1438433-25-0 (E)-6-fluoro-2,3-dihydro-3-[(phenylamino)methylene]-4H-1-benzothiopyran-4-one 
• 1438433-26-1 (E)-3-[[(2-aminophenyl)amino]methylene]-6-fluoro-2,3-dihydro-4H-1-benzothiopyran-4-one 
• 52831-37-5 Fluor-2-methyl-7 6H(1)benzothiopyrano<4,3-b>chinolin 
• 52831-35-3 Fluor-2-6H(I)benzothiopyrano<4,3-b>chinolin 
• 22298-04-0 2-Fluor-6,11-dihydro<1>benzothiopyrano<4,3-b>indol 
• 1315306-72-9 6'-fluoro-3-(4-methoxyphenyl)spiro[oxirane-2,3'-thiochroman]-4'-one 
• 1315306-70-7 6'-fluoro-3-phenyl-spiro[oxirane-2,3'-thiochroman]-4'-one 
• 1315306-69-4 3-(4-chlorophenyl)-6'-fluoro-spiro[oxirane-2,3'-thiochroman]-4'-one 
• 1052544-66-7 6-fluoro-3,4-dihydro-2H-thiochromen-4-amine hydrochloride 
• 52831-42-2 Fluor-2(I)benzothiopyrano<4,3-b>benzoindol 
• 52831-45-5 Fluor-2(I)benzothiopyrano<4,3-b>benzoindol 

Relevant articles and documents

Synthesis of benzothiazonine by rhodium-catalyzed denitrogenative transannulation of 1-sulfonyl-1,2,3-triazole and thiochromone

A facile synthesis of multi-functionalized benzothiazonine was achieved by the rhodium-catalyzed denitrogenative annulation of 1-sulfonyl-1,2,3-triazole and thiochromone. In view of the excellent atom economy, broad substrate scope and easy availability of starting materials, the protocol provided an efficient strategy for the construction of mediumN,S-heterocycles.

Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II

In order to develop potent anticaner agents, a novel series of 3-(1H-indol-3-yl)-2,3,3a,4-tetrahydrothiochromeno[4,3-c]pyrazole derivatives were synthesized. Structures of all compounds were confirmed. MTT assay has been employed to study antiproliferative activity of these compounds with four human cancer cell lines (MGC-803, Hela, MCF-7 and Bel-7404) and a normal cell line L929. Most of these compounds showed potential anticancer activity and low cytotoxicity on normal cell in vitro. 7d and 7f showed the best anticancer activity, whose IC50 value is 15.43 μM and 20.54 μM towards MGC-803, respectively. Most of them exhibited topoisomerase II selective inhibitory. Cleavage reaction assay and DNA unwinding assay showed that 7f was a nonintercalative Topo II catalytic inhibitor, which was consistent with the docking results. Laser scanning confocal microscopy system tracks the location of representative compounds 7d and 7f which can be abundantly entering the nucleus. In particular, the most potent compounds 7d and 7f were shown to be able to induce G2/M cell cycle arrest and apoptosis in MGC-803 cells.

Synthesis and anti cervical cancer activity of novel 5H-thiochromeno [4,3-d]pyrimidines

A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as1H NMR,13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.