4-bromo-1-butoxy-2-methoxybenzene

Base Information

• Chemical Name: 4-bromo-1-butoxy-2-methoxybenzene
• CAS No.: 330475-62-2
• Molecular Formula: C₁₁H₁₅BrO₂
• Molecular Weight: 259.143
• Mol file: 330475-62-2.mol

Synonyms:4-bromo-1-butoxy-2-methoxybenzene

Chemical Property of 4-bromo-1-butoxy-2-methoxybenzene

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-1-butoxy-2-methoxybenzene

There total 1 articles about 4-bromo-1-butoxy-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-bromo-butane (109-65-9) + 4-bromoguaiacol (7368-78-7) → 4-bromo-1-butoxy-2-methoxybenzene (330475-62-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 48h; Inert atmosphere; Reflux;

DOI:10.1021/ja413018f

Reference yield: 83.0%

4-bromo-1-butoxy-2-methoxybenzene (330475-62-2) → (4-butoxy-3-methoxyphenyl)boronic acid (1569688-68-1)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja413018f

Reference yield:

4-bromo-1-butoxy-2-methoxybenzene (330475-62-2) → 1,3,5-tris(4-butoxy-3-methoxybenzyl)benzene (1569688-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Triisopropyl borate; n-butyllithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere

2.1: sodium carbonate / water; acetone / 20 °C / Inert atmosphere; Cooling with ice

2.2: 84 h / 0 - 38 °C / Inert atmosphere

With n-butyllithium; Triisopropyl borate; sodium carbonate; In tetrahydrofuran; hexane; water; acetone; 2.2: |Suzuki Coupling;

DOI:10.1021/ja413018f

upstream raw materials:

1-bromo-butane

4-bromoguaiacol

Downstream raw materials:

(4-butoxy-3-methoxyphenyl)boronic acid

1,3,5-tris(4-butoxy-3-methoxybenzyl)benzene