(E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide
• CAS No.: 1448295-62-2
• Molecular Formula: C₂₇H₃₈N₂O₂S
• Molecular Weight: 454.677
• Mol file: 1448295-62-2.mol

Synonyms:(E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide

Chemical Property of (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide

There total 2 articles about (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(RS)-2-phenylcyclohexanone (1444-65-1) + trisylhydrazine (39085-59-1) → (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide (1448295-62-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol401637n

Reference yield:

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) → (E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide (1448295-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran / 3 h / -10 - 0 °C

2: hydrogenchloride / methanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrazine; In tetrahydrofuran; methanol;

DOI:10.1021/ol401637n

Reference yield:

(E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide (1448295-62-2) → 6-fluoro-2,3,4,5-tetrahydro-1,1'-biphenyl (1448295-66-6) + 1-fluoro-6-phenylcyclohexene

Guidance literature:

(E)-2,4,6-triisopropyl-N'-(2-phenylcyclohexylidene)benzenesulfonohydrazide; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 0 ℃; for 0.833333h;

With 1-fluoro-1,1-bis(phenylsulfonyl)methane; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h; Overall yield = 61 %; Overall yield = 29 mg;

DOI:10.1021/ol401637n

upstream raw materials:

(RS)-2-phenylcyclohexanone

trisylhydrazine

2,4,6-triisopropylphenylsulfonyl chloride

Downstream raw materials:

6-fluoro-2,3,4,5-tetrahydro-1,1'-biphenyl