Technology Process of 3-[5-(2,6-dimethyl-4-phosphonomethoxybenzyl)-2-hydroxyphenyl]propanoic acid
There total 6 articles about 3-[5-(2,6-dimethyl-4-phosphonomethoxybenzyl)-2-hydroxyphenyl]propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C19H21O6P;
With
sodium hydroxide;
In
methanol;
at 20 ℃;
With
hydrogenchloride;
In
methanol; water;
at 0 ℃;
for 0.5h;
pH=1;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanesulfonic acid / dichloromethane / -40 - 0 °C
2.1: trimethylsilyl bromide / dichloromethane / 16 h / 20 °C
3.1: sodium hydroxide / methanol / 20 °C
3.2: 0.5 h / 0 °C / pH 1
With
methanesulfonic acid; trimethylsilyl bromide; sodium hydroxide;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water / 1.5 h / Industry scale
1.2: 4 - 20 °C / Industry scale
1.3: 6.5 h / pH 5 / Industry scale
2.1: caesium carbonate / dimethyl sulfoxide / 8 h / 50 - 60 °C
3.1: methanesulfonic acid / dichloromethane / -40 - 0 °C
4.1: trimethylsilyl bromide / dichloromethane / 16 h / 20 °C
5.1: sodium hydroxide / methanol / 20 °C
5.2: 0.5 h / 0 °C / pH 1
With
methanesulfonic acid; trimethylsilyl bromide; caesium carbonate; sodium hydroxide;
In
methanol; dichloromethane; water; dimethyl sulfoxide;
