4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

Base Information

Chemical Name:4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one
CAS No.:154189-61-4
Molecular Formula:C₂₂H₂₆N₂O₆S₂
Molecular Weight:478.59
Hs Code.:

Synonyms:4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

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Chemical Property of 4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

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Technology Process of 4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

There total 23 articles about 4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 189012-93-9
7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride

: C₂₀H₂₄O₅S

: 154189-61-4
4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

Guidance literature:: With triethylamine; In ethanol; at 75 ℃; for 4.5h; Reflux; Large scale;
DOI:10.1021/op049953y

Reference yield: 66.0%

: 189012-93-9
7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride

: 154189-60-3
2-[3-[2-Phenylethoxy]propylsulphonyl]acetic acid

: 154189-61-4
4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

Guidance literature:: With triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1021/op049953y

Reference yield:

: 60-12-8
2-phenylethanol

: 154189-61-4
4-hydroxy-7-{2-[(2-{[3-(2-phenylethoxy)propyl]sulfonyl}ethyl)amino]ethyl}-1,3-benzothiazol-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 65 - 75 °C / Large scale

2: toluene / 16 h

3: potassium carbonate; Oxone / water; methanol / 18 h

4: triethylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

With Oxone; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op049953y