ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate

Base Information

• Chemical Name: ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate
• CAS No.: 1236188-81-0
• Molecular Formula: C₁₃H₁₀F₃NO₃
• Molecular Weight: 285.223
• Mol file: 1236188-81-0.mol

Synonyms:ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate

Chemical Property of ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate

There total 19 articles about ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(Z/E)-ethyl 2-bromo-4,4,4-trifluorobut-2-enoate (1236144-57-2) + phenylhydroxamoyl chloride (934-16-7) → ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate (1236188-81-0)

Guidance literature:

(Z/E)-ethyl 2-bromo-4,4,4-trifluorobut-2-enoate; phenylhydroxamoyl chloride; With indium(III) chloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

With potassium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 14h;

Reference yield: 72.0%

(Z/E)-ethyl 2-bromo-4,4,4-trifluorobut-2-enoate (1236144-57-2) + benzohydroximoyl chloride (698-16-8) → ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate (1236188-81-0)

Guidance literature:

(Z/E)-ethyl 2-bromo-4,4,4-trifluorobut-2-enoate; benzohydroximoyl chloride; With aluminum (III) chloride; In ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

With potassium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 14h;

Reference yield: 4.6%

ethyl 4,4,4-trifluoro-2-butynate (79424-03-6) + phenylhydroxamoyl chloride (934-16-7) → ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate (1236188-81-0) + ethyl 3-phenyl-5-(trifluoromethyl)isoxazole-4-carboxylate

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃;

upstream raw materials:

ethyl 4,4,4-trifluoro-2-butynate

phenylhydroxamoyl chloride

(Z/E)-ethyl 2-bromo-4,4,4-trifluorobut-2-enoate

benzohydroximoyl chloride

Downstream raw materials:

3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylic acid lithium salt

3-phenyl-4-(trifluoromethyl)isoxazole-5-carbonyl chloride

tert-butyl 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

1-(4-(5-(3-phenyl-4-(trifluoromethyl)-isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid