N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

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Chemical Name:N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide
CAS No.:1310695-80-7
Molecular Formula:C₅₀H₄₈N₆O₄S₂
Molecular Weight:861.101
Hs Code.:

N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

Synonyms:N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

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Chemical Property of N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

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Technology Process of N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

There total 10 articles about N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₄₀N₆O₂S₂

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1310694-75-7
N,N’-(biphenyl-4,4'-diylbis{1,3-thiazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(1R)-2-oxo-1-phenylethane-2,1-diyl]})dicyclopropanecarboxamide

: 1310695-80-7
N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2019.02.016

Reference yield:

: 1007881-98-2
y

: 1310694-75-7
N,N’-(biphenyl-4,4'-diylbis{1,3-thiazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(1R)-2-oxo-1-phenylethane-2,1-diyl]})dicyclopropanecarboxamide

: 1310695-80-7
N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: Lawessons reagent / tetrahydrofuran / 6 h / Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 0.5 h

4.3: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.02.016

Reference yield:

: 1256384-71-0
tert-butyl (2S)-2-[5-(4-bromophenyl)-1,3-thiazol-2-yl]pyrrolidine-1-carboxylate

: 1310694-75-7
N,N’-(biphenyl-4,4'-diylbis{1,3-thiazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(1R)-2-oxo-1-phenylethane-2,1-diyl]})dicyclopropanecarboxamide

: 1310695-80-7
N-[(1R)-2-{(2S)-2-[5-(4’-{2-[(2S)-1-{(2S)-2-[(cyclopropylcarbonyl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-1,3-thiazol-5-yl}biphenyl-4-yl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxo-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 0.5 h

3.3: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

5.1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2019.02.016