N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Base Information

• Chemical Name: N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine
• CAS No.: 1191385-20-2
• Molecular Formula: C₃₁H₂₇ClN₈O
• Molecular Weight: 563.061
• Mol file: 1191385-20-2.mol

Synonyms:N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Chemical Property of N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine

There total 1 articles about N₁-(4-chlorophenyl)-6-methyl-N₅-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine (1093101-72-4) + 6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine (1093101-52-0) → N1-(4-chlorophenyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1191385-20-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm901081g

Reference yield: 73.0%

N1-(4-chlorophenyl)-6-methyl-N5-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)isoquinoline-1,5-diamine (1191385-20-2) → N5-(3-(9H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine dihydrochloride

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1021/jm901081g

upstream raw materials:

N¹-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine

6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine