5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Base Information

Chemical Name:5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran
CAS No.:138854-19-0
Molecular Formula:C₃₃H₃₁NO₃
Molecular Weight:489.614
Hs Code.:

Synonyms:5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Suppliers and Price of 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

There total 12 articles about 5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 767-00-0
4-cyanophenol

: 138854-18-9
5-(benzyloxy)-6-(3-bromopropyl)-2,3-dihydro-2-(2-phenylethyl)benzofuran

: 138853-91-5
2,3-dihydro-2-(2-phenylethyl)-6-<3-<4-(1H-tetrazol-5-yl)phenoxy>propyl>-5-benzofuranol

: 138854-19-0
5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Guidance literature:: In N-methyl-acetamide; hexane; ethyl acetate;

Reference yield:

: 13391-28-1
5-methoxybenzofuran

: 138854-19-0
5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C

2: 58 percent / AlCl₃, tert-butylamine-borane / toluene / 2 h / 5 °C

3: 99 percent / trifluoroacetic acid, triethylsilane / 1.) 5 deg C, 60 min, 2.) RT, 18 h

4: 98 percent / ethanethiol, lithium hydride / dimethylformamide / 3 h / Heating

5: 82 percent / K₂CO₃ / acetone / 18 h / Heating

6: 69.5 percent / 1,2-dichloro-benzene / 21 h / Heating

7: K₂CO₃ / butan-2-one / 22 h / Heating

8: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

9: CBr₄, triphenylphosphine / CH₂Cl₂ / 0.75 h

10: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 18 h

With triethylsilane; sodium hydroxide; n-butyllithium; aluminium trichloride; borane-THF; carbon tetrabromide; dihydrogen peroxide; lithium hydride; sodium hydride; borane tert-butylamine; potassium carbonate; triphenylphosphine; trifluoroacetic acid; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; toluene; butanone;
DOI:10.1021/jm00085a019

Reference yield:

: 122-78-1
phenylacetaldehyde

: 138854-19-0
5-(benzyloxy)-6-<3-(4-cyanophenoxy)propyl>-2,3-dihydro-2-(2-phenylethyl)benzofuran

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C

2: 58 percent / AlCl₃, tert-butylamine-borane / toluene / 2 h / 5 °C

3: 99 percent / trifluoroacetic acid, triethylsilane / 1.) 5 deg C, 60 min, 2.) RT, 18 h

4: 98 percent / ethanethiol, lithium hydride / dimethylformamide / 3 h / Heating

5: 82 percent / K₂CO₃ / acetone / 18 h / Heating

6: 69.5 percent / 1,2-dichloro-benzene / 21 h / Heating

7: K₂CO₃ / butan-2-one / 22 h / Heating

8: 1.) BH₃*THF, 2.) a) 30percent aq. H₂O₂, 1 N aq. NaOH, b) NaS / 1.) 0 deg C, 75 min, 2.) a) THF, methanol, 30 min, b) H₂O

9: CBr₄, triphenylphosphine / CH₂Cl₂ / 0.75 h

10: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 18 h

With triethylsilane; sodium hydroxide; n-butyllithium; aluminium trichloride; borane-THF; carbon tetrabromide; dihydrogen peroxide; lithium hydride; sodium hydride; borane tert-butylamine; potassium carbonate; triphenylphosphine; trifluoroacetic acid; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; toluene; butanone;
DOI:10.1021/jm00085a019