2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

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Chemical Name:2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide
CAS No.:1357588-06-7
Molecular Formula:C₂₉H₃₁F₃N₆O₃S
Molecular Weight:600.665
Hs Code.:

Synonyms:2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

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Chemical Property of 2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

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Technology Process of 2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

There total 10 articles about 2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357588-06-7
2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

7.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

8.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

9.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 20 °C

9.2: 4 h / 80 °C

With pyridine; N-Bromosuccinimide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1357588-05-6
2,5-difluoro-N-{2-fluoro-3-[1-(2-hydroxyethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide

: 1357588-06-7
2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

Guidance literature:: 2,5-difluoro-N-{2-fluoro-3-[1-(2-hydroxyethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 1h;

1-methyl-piperazine; In acetonitrile; at 80 ℃; for 4h;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1357588-06-7
2,5-difluoro-N-(2-fluoro-3-{1-[2-(4-methylpiperazin-1-yl)ethyl]-4-pyridin-4-yl-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 1 h / 0 °C

7.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

8.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

9.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 20 °C

9.2: 4 h / 80 °C

With pyridine; N-Bromosuccinimide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;