4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

Base Information

Chemical Name:4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester
CAS No.:685881-28-1
Molecular Formula:C₂₅H₂₇IO₇
Molecular Weight:566.39
Hs Code.:

Synonyms:4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

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Chemical Property of 4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

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Technology Process of 4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

There total 1 articles about 4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 685881-15-6
4-(6-allyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-but-2-ynoic acid ethyl ester

: 685881-28-1
4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

Guidance literature:: With acetic acid; sodium iodide; at 115 ℃; for 4.5h;
DOI:10.1021/ol049649p

Reference yield: 77.0%

: 685881-28-1
4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

: 685881-29-2
4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ol049649p

Reference yield:

: 685881-28-1
4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester

: 5-(3,4,5-trimethoxy-phenyl)-5,9-dihydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77 percent / DIBAL-H / CH₂Cl₂ / 0 - 20 °C

2.1: 91 percent / triphenylphosphine; silver(I) carbonate; palladium(II) acetate / benzene / 1 h / Heating

3.1: 89 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

4.1: 80 percent / oxygen; 5,10,15,20-tetraphenylporphyrin / CCl₄ / 7 h / 0 °C / Irradiation

5.1: 96 percent / aluminum amalgam / tetrahydrofuran; H₂O / 2.5 h / 20 °C

6.1: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 0 °C

7.1: sodium hydrogen carbonate; lead tetraacetate / CH₂Cl₂ / 0.25 h / 0 °C

7.2: 36 percent / pyridinium dichromate / CH₂Cl₂ / 0.5 h

With lead(IV) acetate; dmap; aluminium amalgam; tetrabutyl ammonium fluoride; oxygen; palladium diacetate; 5,15,10,20-tetraphenylporphyrin; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; silver carbonate; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; benzene; 2.1: Heck reaction;
DOI:10.1021/ol049649p