1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

Base Information

Chemical Name:1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one
CAS No.:1048034-29-2
Molecular Formula:C₃₂H₄₁ClN₆O₃S
Molecular Weight:625.235
Hs Code.:

1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

Synonyms:1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

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Chemical Property of 1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

There total 10 articles about 1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1048035-06-8
2-chloro-5-(5-methanesulfonyl-1-{3-[4-(2-oxo-pyrrolidin-1-yl)-piperidin-1-yl]-propyl}-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzaldehyde

: 62-53-3
aniline

: 1048034-29-2
1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

Guidance literature:: 2-chloro-5-(5-methanesulfonyl-1-{3-[4-(2-oxo-pyrrolidin-1-yl)-piperidin-1-yl]-propyl}-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzaldehyde; aniline; With acetic acid; In dichloromethane; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1048034-93-0
C₁₁H₂₀N₂O₂S

: 1048034-29-2
1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

3.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

4.1: acetic acid / dichloromethane / 0.25 h

4.2: 17 h / 20 °C

5.1: pyridine; sodium hypophosphite; acetic acid / nickel / water / 19 h / 20 - 60 °C

6.1: acetic acid / dichloromethane / 0.5 h

6.2: 18 h / 20 °C

With pyridine; hydrogenchloride; sodium hypophosphite; water; caesium carbonate; acetic acid; triethylamine; nickel; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1048035-05-7
C₁₇H₁₇ClN₄O₃S

: 1048034-29-2
1-(1-(3-[3-(4-chloro-3-phenylaminomethyl-phenyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl)-piperidin-4-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.25 h

1.2: 17 h / 20 °C

2.1: pyridine; sodium hypophosphite; acetic acid / nickel / water / 19 h / 20 - 60 °C

3.1: acetic acid / dichloromethane / 0.5 h

3.2: 18 h / 20 °C

With pyridine; sodium hypophosphite; acetic acid; nickel; In dichloromethane; water;