ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate

Base Information

• Chemical Name: ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate
• CAS No.: 1620240-08-5
• Molecular Formula: C₂₄H₂₅N₃O₅
• Molecular Weight: 435.48
• Mol file: 1620240-08-5.mol

Synonyms:ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate

Chemical Property of ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate

There total 3 articles about ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

morpholine (110-91-8,99108-56-2) + ethyl 3-{[(benzyloxy)carbonyl]amino}-7-bromoquinoline-2-carboxylate (1620239-11-3) → ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate (1620240-08-5)

Guidance literature:

With potassium phosphate; palladium diacetate; ruphos; In tert-butyl alcohol; at 100 ℃; for 1h; Sealed tube; Inert atmosphere;

Reference yield:

ethyl 3-amino-7-bromoquinoline-2-carboxylate (1260807-99-5) → ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate (1620240-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / -10 - 20 °C

2: potassium phosphate; palladium diacetate; ruphos / tert-butyl alcohol / 1 h / 100 °C / Sealed tube; Inert atmosphere

With pyridine; potassium phosphate; palladium diacetate; ruphos; In dichloromethane; tert-butyl alcohol;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate (1620240-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / -10 - 20 °C

2: potassium phosphate; palladium diacetate; ruphos / tert-butyl alcohol / 1 h / 100 °C / Sealed tube; Inert atmosphere

With pyridine; potassium phosphate; palladium diacetate; ruphos; In dichloromethane; tert-butyl alcohol;

upstream raw materials:

morpholine

ethyl 3-{[(benzyloxy)carbonyl]amino}-7-bromoquinoline-2-carboxylate

ethyl 3-amino-7-bromoquinoline-2-carboxylate

benzyl chloroformate

Downstream raw materials:

3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylic acid

benzyl [2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)-7-morpholin-4-ylquinolin-3-yl]carbamate

benzyl {2-[({4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]-7-morpholin-4-ylquinolin-3-yl}carbamate

tert-butyl methyl [(3R,4S,5S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinolin-2-yl)carbonyl]amino}pyridin-4-yl)-5-methylpiperidine-3,4-diyl]biscarbamate