o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Base Information

Chemical Name:o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine
CAS No.:97205-05-5
Molecular Formula:C₄₄H₇₀ClN₁₀O₁₀PSi₃
Molecular Weight:1049.78
Hs Code.:

Synonyms:o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Suppliers and Price of o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Chemical Property:

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Technology Process of o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

There total 8 articles about o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₄H₈₆ClN₁₀O₁₁PSi₃

: 97205-05-5
o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Guidance literature:: With dichloro-acetic acid; In dichloromethane; at 25 ℃; for 2h; Yield given;
DOI:10.1016/S0040-4039(00)89130-3

Reference yield:

: 72677-42-0
o-chlorophenyl p-nitrophenyl phosphorochloridate

: 97205-05-5
o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, 18 deg C, 2 h

2: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, DMF, 18 deg C, 12 h

3: dichloroacetic acid / 2 h / 18 °C

With dichloro-acetic acid; tert-butylmagnesium chloride;

Reference yield:

: 69504-05-8
3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

: 97205-05-5
o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, 18 deg C, 2 h

2: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, DMF, 18 deg C, 12 h

3: dichloroacetic acid / 2 h / 18 °C

With dichloro-acetic acid; tert-butylmagnesium chloride;