Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

Base Information

Chemical Name:Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester
CAS No.:97205-04-4
Molecular Formula:C₄₈H₅₀ClN₆O₁₀PSi
Molecular Weight:965.471
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

There total 4 articles about Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 97205-04-4
Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / imidazole / dimethylformamide / 3 h / 27 °C

2: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, 18 deg C, 2 h

With 1H-imidazole; tert-butylmagnesium chloride; In N,N-dimethyl-formamide;

Reference yield:

: 51600-11-4
5'-O-(p-methoxyphenyldiphenylmethyl)adenosine

: 97205-04-4
Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / imidazole / dimethylformamide / 3 h / 27 °C

2: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, 18 deg C, 2 h

With 1H-imidazole; tert-butylmagnesium chloride; In N,N-dimethyl-formamide;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 97205-04-4
Phosphoric acid (2R,3R,4R,5R)-2-(6-amino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / MgCl₂ / 10 h / 45 - 120 °C

2: 1.) t-BuMgCl / 1.) THF, 18 deg C, 5 min, 2.) THF, 18 deg C, 2 h

With tert-butylmagnesium chloride; magnesium chloride;