2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Base Information

Chemical Name:2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid
CAS No.:1219126-93-8
Molecular Formula:C₁₆H₁₈N₂O₇P₂
Molecular Weight:412.276
Hs Code.:

Synonyms:2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

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Chemical Property of 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

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Technology Process of 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

There total 3 articles about 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1219127-03-3
[2-(8-benzyloxy-imidazo[1,2-a]pyridin-3-yl)-1-(diethyl-phosphoryl)-ethyl]-phosphonic acid diethyl ester

: 1219126-93-8
2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Guidance literature:: [2-(8-benzyloxy-imidazo[1,2-a]pyridin-3-yl)-1-(diethyl-phosphoryl)-ethyl]-phosphonic acid diethyl ester; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

With water; In dichloromethane;

Reference yield:

: 885276-38-0
8-benzyloxy-3-iodo-imidazo[1,2-a]pyridine

: 1219126-93-8
2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With n-butyllithium; trimethylsilyl bromide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 96428-16-9
8-(phenylmethoxy)imidazo[1,2-a]pyridine

: 1219126-93-8
2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / acetonitrile / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere

2.2: -70 - 20 °C

3.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; n-butyllithium; trimethylsilyl bromide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;