Technology Process of 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid
There total 3 articles about 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[2-(8-benzyloxy-imidazo[1,2-a]pyridin-3-yl)-1-(diethyl-phosphoryl)-ethyl]-phosphonic acid diethyl ester;
With
trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
for 24h;
Inert atmosphere;
With
water;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere
1.2: -70 - 20 °C
2.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
n-butyllithium; trimethylsilyl bromide;
In
tetrahydrofuran; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-iodo-succinimide / acetonitrile / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere
2.2: -70 - 20 °C
3.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With
N-iodo-succinimide; n-butyllithium; trimethylsilyl bromide;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;