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2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Base Information Edit
  • Chemical Name:2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid
  • CAS No.:1219126-93-8
  • Molecular Formula:C16H18N2O7P2
  • Molecular Weight:412.276
  • Hs Code.:
  • Mol file:1219126-93-8.mol
2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

Synonyms:2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

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Chemical Property of 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid Edit
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Technology Process of 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid

There total 3 articles about 2-(8-(benzyloxy)imidazo[1,2-a]pyridin-3-yl)-1-ethane-1,1-bisphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
[2-(8-benzyloxy-imidazo[1,2-a]pyridin-3-yl)-1-(diethyl-phosphoryl)-ethyl]-phosphonic acid diethyl ester; With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
With water; In dichloromethane;
Guidance literature:
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere
1.2: -70 - 20 °C
2.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With n-butyllithium; trimethylsilyl bromide; In tetrahydrofuran; hexane; dichloromethane;
Guidance literature:
Multi-step reaction with 3 steps
1.1: N-iodo-succinimide / acetonitrile / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere
2.2: -70 - 20 °C
3.1: trimethylsilyl bromide / dichloromethane / 24 h / 20 °C / Inert atmosphere
With N-iodo-succinimide; n-butyllithium; trimethylsilyl bromide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
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