((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

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Chemical Name:((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol
CAS No.:1206481-32-4
Molecular Formula:C₃₀H₄₆O₆Si
Molecular Weight:530.777
Hs Code.:

Synonyms:((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

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Chemical Property of ((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

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Technology Process of ((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

There total 1 articles about ((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1206481-31-3
((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methyl pivalate

: 1206481-32-4
((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

Guidance literature:: ((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methyl pivalate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -80 ℃; for 2h; Inert atmosphere;

With water; ammonium chloride; In hexane; dichloromethane; at -80 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.11.024

Reference yield: 89.0%

: 1206481-32-4
((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1206481-33-5
2-((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)acetonitrile

Guidance literature:: ((2S,4R,5S,6S)-6-((R)-4-(tert-butyldimethylsilyloxy)-pentyl)-5-(4-methoxybenzyloxy)-2-phenyl-1,3-dioxan-4-yl)methanol; With triphenylphosphine; diethylazodicarboxylate; In diethyl ether; at -5 ℃; Inert atmosphere;

2-hydroxy-2-methylpropanenitrile; In diethyl ether; at -5 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2009.11.024