(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

Base Information

Chemical Name:(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane
CAS No.:527729-80-2
Molecular Formula:C₁₇H₂₈O₃SSi
Molecular Weight:340.559
Hs Code.:

Synonyms:(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

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Chemical Property of (-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

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Technology Process of (-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

There total 7 articles about (-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 527729-63-1
(-)-(1R,2R)-2-(2-benzenesulfonylvinyl)-1-tert-butyldimethylsililoxy-cyclopropane

: 527729-80-2
(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; for 22h;
DOI:10.1055/s-2003-36256

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 527729-80-2
(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 2,6-lutidine / tetrahydrofuran / 0.5 h / 20 °C

2: LDA / tetrahydrofuran / 0.75 h / -78 °C

3: 66 percent / H₂ / PtO₂ / ethyl acetate / 22 h

With 2,6-dimethylpyridine; hydrogen; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate;
DOI:10.1055/s-2003-36256

Reference yield:

: 219926-63-3
(+)-(4S)-2,2-Dimethyl-4-[(E)-3-phenylsulfonylprop-1-enyl]-1,3-dioxolane

: 527729-80-2
(-)-(1R,2R)-2-(2-benzenesulfonylethyl)-1-tert-butyldimethylsililoxy-cyclopropane

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / aq. HCl / methanol / 2 h / 20 °C

2: 70 percent / pyridine / 16 h / 20 °C

3: 94 percent / NaI / acetone / 5 h / 80 °C

4: 98 percent / 2,6-lutidine / tetrahydrofuran / 0.5 h / 20 °C

5: LDA / tetrahydrofuran / 0.75 h / -78 °C

6: 66 percent / H₂ / PtO₂ / ethyl acetate / 22 h

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; hydrogen; sodium iodide; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; acetone;
DOI:10.1055/s-2003-36256