N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

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Chemical Name:N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine
CAS No.:1264499-36-6
Molecular Formula:C₄₇H₆₂N₄O₈
Molecular Weight:811.031
Hs Code.:

Synonyms:N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

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Chemical Property of N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

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Technology Process of N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

There total 7 articles about N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1264499-18-4
N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

: 1264499-14-0
N₁-[3,4-bis(benzyloxy)-benzoyl]-N₈-tert-butyloxycarbonyl-spermidine

: 1264499-36-6
N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

Guidance literature:: N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

N₁-[3,4-bis(benzyloxy)-benzoyl]-N₈-tert-butyloxycarbonyl-spermidine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201005527

Reference yield:

: 1264499-11-7
3,4-bis(benzyloxy)-N-(3-oxopropyl)-benzamide

: 1264499-36-6
N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 1 h / 20 °C / pH 8 / Molecular sieve; Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / methanol / 48 h / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201005527

Reference yield:

: 1264499-32-2
3,4-bis(benzyloxy)-N-(3,3-diethoxypropyl)-benzamide

: 1264499-36-6
N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / water; acetone / 4 h / 50 °C / Inert atmosphere

2.1: triethylamine / methanol / 1 h / 20 °C / pH 8 / Molecular sieve; Inert atmosphere

3.1: sodium tris(acetoxy)borohydride / methanol / 48 h / Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.201005527