N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

Base Information

Chemical Name:N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid
CAS No.:1264499-18-4
Molecular Formula:C₁₄H₂₁NO₄
Molecular Weight:267.325
Hs Code.:

Synonyms:N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

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Chemical Property of N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

Chemical Property:

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Technology Process of N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

There total 1 articles about N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 94142-97-9
2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione

: 56-12-2
4-amino-n-butyric acid

: 1264499-18-4
N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

Guidance literature:: With trifluoroacetic acid; In ethanol; at 45 ℃; Molecular sieve; Inert atmosphere;
DOI:10.1002/anie.201005527

Reference yield: 96.0%

: 1264499-18-4
N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

: 1264499-14-0
N₁-[3,4-bis(benzyloxy)-benzoyl]-N₈-tert-butyloxycarbonyl-spermidine

: 1264499-36-6
N1-[3,4-bis(benzyloxy)-benzoyl]-N8-tert-butyloxycarbonyl-N4-[N-{1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)}-γ-aminobutyryl]-spermidine

Guidance literature:: N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

N₁-[3,4-bis(benzyloxy)-benzoyl]-N₈-tert-butyloxycarbonyl-spermidine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201005527

Reference yield:

: 1264499-18-4
N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl]-γ-aminobutyric acid

: 1264499-26-4
1-{N1-[3,4-bis(benzyloxy)-benzoyl]-N4-[1-((4,4-dimethyl-2,6-dioxocyclohexylidene)-ethyl)-γ-aminobutyryl]-spermidinyl}-2-tert-butyl citrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Molecular sieve; Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201005527