1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine

Base Information

• Chemical Name: 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine
• CAS No.: 1608469-56-2
• Molecular Formula: C₁₉H₂₂F₂N₂O₄S
• Molecular Weight: 418.434

Synonyms:1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine

Chemical Property of 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine

Chemical Property:

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Technology Process of 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine

There total 7 articles about 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([³H]methyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazin-1-ium chloride + [3H3]-methylnosylate → 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([3H]methyl)-piperazine (1608469-56-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

tert-butyl 4-(5-iodo-2-methoxyphenyl)piperazine-1-carboxylate (1608469-58-4) → 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([3H]methyl)-piperazine (1608469-56-2)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride / toluene / 8 h / 80 °C / Inert atmosphere

2: hydrogenchloride / ethanol; isopropyl alcohol / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

tert-butyl 4-(2-methoxy-5-nitrophenyl)piperazine-1-carboxylate (177488-99-2) → 1-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)-4-([3H]methyl)-piperazine (1608469-56-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 1 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 0 °C

2.2: 0.17 h / 0 °C

2.3: 2 h / 0 - 5 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride / toluene / 8 h / 80 °C / Inert atmosphere

4.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl-ammonium chloride; ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In ethanol; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile;

upstream raw materials:

tert-butyl 4-(2-methoxy-5-nitrophenyl)piperazine-1-carboxylate

tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate

tert-butyl 4-(5-iodo-2-methoxyphenyl)piperazine-1-carboxylate

3-(difluoromethoxy)benzene-1-sulfonyl chloride

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